diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index f08f2d996af..b609a64f8d7 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -14076,6 +14076,11 @@ namespace ts {
 
         function checkJsxFragment(node: JsxFragment): Type {
             checkJsxOpeningLikeElementOrOpeningFragment(node.openingFragment);
+
+            if (compilerOptions.jsx === JsxEmit.React && compilerOptions.jsxFactory) {
+                error(node, Diagnostics.JSX_fragment_is_not_supported_when_using_jsxFactory);
+            }
+
             return getJsxGlobalElementType() || anyType;
         }
 
diff --git a/src/compiler/diagnosticMessages.json b/src/compiler/diagnosticMessages.json
index d89f631f28e..de3fc544fa5 100644
--- a/src/compiler/diagnosticMessages.json
+++ b/src/compiler/diagnosticMessages.json
@@ -3615,6 +3615,10 @@
         "category": "Error",
         "code": 17015
     },
+    "JSX fragment is not supported when using --jsxFactory": {
+        "category": "Error",
+        "code":17016
+    },
 
     "Circularity detected while resolving configuration: {0}": {
         "category": "Error",