diff --git a/shells/browser/shared/src/panel.js b/shells/browser/shared/src/panel.js
index 67f0584dc0..c1e837ed4a 100644
--- a/shells/browser/shared/src/panel.js
+++ b/shells/browser/shared/src/panel.js
@@ -1,7 +1,7 @@
 /* global chrome */
 
 import { createElement } from 'react';
-import { render } from 'react-dom';
+import { render, unmountComponentAtNode } from 'react-dom';
 import Bridge from 'src/bridge';
 import Elements from 'src/devtools/views/Elements';
 import inject from './inject';
@@ -36,27 +36,56 @@ if (IS_CHROME) {
 
 const node = ((document.getElementById('container'): any): HTMLElement);
 
-inject(chrome.runtime.getURL('build/backend.js'), () => {
-  let disconnected = false;
+function reloadDevTools() {
+  setTimeout(() => {
+    unmountComponentAtNode(node);
 
-  const port = chrome.runtime.connect({
-    name: '' + chrome.devtools.inspectedWindow.tabId,
-  });
-  port.onDisconnect.addListener(() => {
-    disconnected = true;
-  });
+    node.innerHTML = '';
 
-  const bridge = new Bridge({
-    listen(fn) {
-      port.onMessage.addListener(message => fn(message));
-    },
-    send(event: string, payload: any, transferable?: Array<any>) {
-      if (disconnected) {
-        return;
-      }
-      port.postMessage({ event, payload }, transferable);
-    },
-  });
+    injectAndInit();
+  }, 100);
+}
 
-  render(createElement(Elements, { bridge, browserName, themeName }), node);
-});
+function injectAndInit() {
+  inject(chrome.runtime.getURL('build/backend.js'), () => {
+    let disconnected = false;
+
+    const port = chrome.runtime.connect({
+      name: '' + chrome.devtools.inspectedWindow.tabId,
+    });
+    port.onDisconnect.addListener(() => {
+      disconnected = true;
+    });
+
+    const bridge = new Bridge({
+      listen(fn) {
+        port.onMessage.addListener(message => fn(message));
+      },
+      send(event: string, payload: any, transferable?: Array<any>) {
+        if (disconnected) {
+          return;
+        }
+        port.postMessage({ event, payload }, transferable);
+      },
+    });
+
+    // Reload the DevTools extension when the user navigates to a new page.
+    function onNavigated() {
+      chrome.devtools.network.onNavigated.removeListener(onNavigated);
+      bridge.send('shutdown');
+      reloadDevTools();
+    }
+    chrome.devtools.network.onNavigated.addListener(onNavigated);
+
+    render(
+      createElement(Elements, {
+        bridge,
+        browserName,
+        themeName,
+      }),
+      node
+    );
+  });
+}
+
+injectAndInit();
diff --git a/src/backend/agent.js b/src/backend/agent.js
index 6d7b1a3c03..d33a594321 100644
--- a/src/backend/agent.js
+++ b/src/backend/agent.js
@@ -24,6 +24,8 @@ export default class Agent extends EventEmitter {
   addBridge(bridge: Bridge) {
     this._bridge = bridge;
 
+    bridge.on('shutdown', () => this.emit('shutdown'));
+
     // TODO Listen to bridge for things like selection.
     // bridge.on('...'), this...);
   }
diff --git a/src/backend/index.js b/src/backend/index.js
index a634b9c8aa..029bd655c4 100644
--- a/src/backend/index.js
+++ b/src/backend/index.js
@@ -43,6 +43,9 @@ export function initBackend(hook: Hook, agent: Agent): void {
   hook.reactDevtoolsAgent = agent;
   agent.addListener('shutdown', () => {
     subs.forEach(fn => fn());
+    for (let id in hook.rendererInterfaces) {
+      hook.rendererInterfaces[id].cleanup();
+    }
     hook.reactDevtoolsAgent = null;
   });
 }
diff --git a/src/devtools/views/Elements.js b/src/devtools/views/Elements.js
index 60afcc048c..abf2829dae 100644
--- a/src/devtools/views/Elements.js
+++ b/src/devtools/views/Elements.js
@@ -14,7 +14,11 @@ export type Props = {|
   themeName: string,
 |};
 
-export default function Elements({ bridge, browserName, themeName }: Props) {
+export default function Elements({
+  bridge,
+  browserName,
+  themeName,
+}: Props) {
   const store = useMemo<Store>(() => new Store(bridge), []);
 
   const [treeContext, setTreeContext] = useState({