diff --git a/src/__tests__/profilerStore-test.js b/src/__tests__/profilerStore-test.js
index 08f64b344b..f6ffcfe783 100644
--- a/src/__tests__/profilerStore-test.js
+++ b/src/__tests__/profilerStore-test.js
@@ -54,4 +54,21 @@ describe('ProfilerStore', () => {
 
     expect(store.profilerStore.getDataForRoot(rootB)).not.toBeNull();
   });
+
+  it('should not allow new/saved profiling data to be set while profiling is in progress', () => {
+    utils.act(() => store.profilerStore.startProfiling());
+    const fauxProfilingData = {
+      dataForRoots: new Map(),
+    };
+    spyOn(console, 'warn');
+    store.profilerStore.profilingData = fauxProfilingData;
+    expect(store.profilerStore.profilingData).not.toBe(fauxProfilingData);
+    expect(console.warn).toHaveBeenCalledTimes(1);
+    expect(console.warn).toHaveBeenCalledWith(
+      'Profiling data cannot be updated while profiling is in progress.'
+    );
+    utils.act(() => store.profilerStore.stopProfiling());
+    store.profilerStore.profilingData = fauxProfilingData;
+    expect(store.profilerStore.profilingData).toBe(fauxProfilingData);
+  });
 });
diff --git a/src/devtools/ProfilerStore.js b/src/devtools/ProfilerStore.js
index 30e1934600..f4901287ea 100644
--- a/src/devtools/ProfilerStore.js
+++ b/src/devtools/ProfilerStore.js
@@ -144,6 +144,13 @@ export default class ProfilerStore extends EventEmitter {
     return this._dataFrontend;
   }
   set profilingData(value: ProfilingDataFrontend | null): void {
+    if (this._isProfiling) {
+      console.warn(
+        'Profiling data cannot be updated while profiling is in progress.'
+      );
+      return;
+    }
+
     this._dataBackends.splice(0);
     this._dataFrontend = value;
     this._initialRendererIDs.clear();