diff --git a/packages/react-dom/src/events/DOMPluginEventSystem.js b/packages/react-dom/src/events/DOMPluginEventSystem.js
index 114d8239fd..60f7e5b828 100644
--- a/packages/react-dom/src/events/DOMPluginEventSystem.js
+++ b/packages/react-dom/src/events/DOMPluginEventSystem.js
@@ -778,7 +778,8 @@ export function accumulateSinglePhaseListeners(
       enableCreateEventHandleAPI &&
       enableScopeAPI &&
       tag === ScopeComponent &&
-      lastHostComponent !== null
+      lastHostComponent !== null &&
+      stateNode !== null
     ) {
       const reactScopeInstance = stateNode;
       const eventHandlerlisteners = getEventHandlerListeners(