diff --git a/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm b/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm
index 2783342928d..f207e642a96 100644
--- a/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm
+++ b/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm
@@ -327,6 +327,28 @@ static void RCTSendPaperScrollEvent_DEPRECATED(UIScrollView *scrollView, NSInteg
   }
 }
 
+/*
+ * Returns whether or not the scroll view interaction should be blocked because
+ * JavaScript was found to be the responder.
+ */
+- (BOOL)_shouldDisableScrollInteraction
+{
+  UIView *ancestorView = self.superview;
+
+  while (ancestorView) {
+    if ([ancestorView respondsToSelector:@selector(isJSResponder)]) {
+      BOOL isJSResponder = ((UIView<RCTComponentViewProtocol> *)ancestorView).isJSResponder;
+      if (isJSResponder) {
+        return YES;
+      }
+    }
+
+    ancestorView = ancestorView.superview;
+  }
+
+  return NO;
+}
+
 - (ScrollViewMetrics)_scrollViewMetrics
 {
   ScrollViewMetrics metrics;
@@ -366,7 +388,7 @@ static void RCTSendPaperScrollEvent_DEPRECATED(UIScrollView *scrollView, NSInteg
 {
   // Historically, `UIScrollView`s in React Native do not cancel touches
   // started on `UIControl`-based views (as normal iOS `UIScrollView`s do).
-  return YES;
+  return ![self _shouldDisableScrollInteraction];
 }
 
 - (void)scrollViewDidScroll:(UIScrollView *)scrollView
diff --git a/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm b/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm
index dce5d37e5c9..9a302655b69 100644
--- a/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm
+++ b/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm
@@ -23,6 +23,7 @@ using namespace facebook::react;
   UIColor *_backgroundColor;
   CALayer *_borderLayer;
   BOOL _needsInvalidateLayer;
+  BOOL _isJSResponder;
   NSSet<NSString *> *_Nullable _propKeysManagedByAnimated_DO_NOT_USE_THIS_IS_BROKEN;
 }
 
@@ -284,6 +285,16 @@ using namespace facebook::react;
   }
 }
 
+- (BOOL)isJSResponder
+{
+  return _isJSResponder;
+}
+
+- (void)setIsJSResponder:(BOOL)isJSResponder
+{
+  _isJSResponder = isJSResponder;
+}
+
 - (void)finalizeUpdates:(RNComponentViewUpdateMask)updateMask
 {
   [super finalizeUpdates:updateMask];
@@ -310,6 +321,7 @@ using namespace facebook::react;
 
   _propKeysManagedByAnimated_DO_NOT_USE_THIS_IS_BROKEN = nil;
   _eventEmitter.reset();
+  _isJSResponder = NO;
 }
 
 - (void)setPropKeysManagedByAnimated_DO_NOT_USE_THIS_IS_BROKEN:(NSSet<NSString *> *_Nullable)props
diff --git a/React/Fabric/Mounting/RCTComponentViewProtocol.h b/React/Fabric/Mounting/RCTComponentViewProtocol.h
index 8183e419202..11493c42798 100644
--- a/React/Fabric/Mounting/RCTComponentViewProtocol.h
+++ b/React/Fabric/Mounting/RCTComponentViewProtocol.h
@@ -116,6 +116,9 @@ typedef NS_OPTIONS(NSInteger, RNComponentViewUpdateMask) {
  */
 - (facebook::react::SharedProps)props;
 
+- (BOOL)isJSResponder;
+- (void)setIsJSResponder:(BOOL)isJSResponder;
+
 /*
  * This is broken. Do not use.
  */
diff --git a/React/Fabric/Mounting/RCTMountingManager.h b/React/Fabric/Mounting/RCTMountingManager.h
index f610ee965af..ea1e1d8650c 100644
--- a/React/Fabric/Mounting/RCTMountingManager.h
+++ b/React/Fabric/Mounting/RCTMountingManager.h
@@ -58,6 +58,8 @@ NS_ASSUME_NONNULL_BEGIN
  */
 - (void)sendAccessibilityEvent:(ReactTag)reactTag eventType:(NSString *)eventType;
 
+- (void)setIsJSResponder:(BOOL)isJSResponder forShadowView:(facebook::react::ShadowView)shadowView;
+
 - (void)synchronouslyUpdateViewOnUIThread:(ReactTag)reactTag
                              changedProps:(NSDictionary *)props
                       componentDescriptor:(facebook::react::ComponentDescriptor const &)componentDescriptor;
diff --git a/React/Fabric/Mounting/RCTMountingManager.mm b/React/Fabric/Mounting/RCTMountingManager.mm
index 4de3f5593bf..b5555757eae 100644
--- a/React/Fabric/Mounting/RCTMountingManager.mm
+++ b/React/Fabric/Mounting/RCTMountingManager.mm
@@ -259,6 +259,15 @@ static void RCTPerformMountInstructions(
       });
 }
 
+- (void)setIsJSResponder:(BOOL)isJSResponder forShadowView:(facebook::react::ShadowView)shadowView
+{
+  RCTExecuteOnMainQueue(^{
+    UIView<RCTComponentViewProtocol> *componentView =
+        [self->_componentViewRegistry findComponentViewWithTag:shadowView.tag];
+    [componentView setIsJSResponder:isJSResponder];
+  });
+}
+
 - (void)synchronouslyUpdateViewOnUIThread:(ReactTag)reactTag
                              changedProps:(NSDictionary *)props
                       componentDescriptor:(const ComponentDescriptor &)componentDescriptor
diff --git a/React/Fabric/Mounting/UIView+ComponentViewProtocol.h b/React/Fabric/Mounting/UIView+ComponentViewProtocol.h
index 3cb45b8f7b7..0a9579ed7a5 100644
--- a/React/Fabric/Mounting/UIView+ComponentViewProtocol.h
+++ b/React/Fabric/Mounting/UIView+ComponentViewProtocol.h
@@ -39,6 +39,8 @@ NS_ASSUME_NONNULL_BEGIN
 
 - (facebook::react::SharedProps)props;
 
+- (void)setIsJSResponder:(BOOL)isJSResponder;
+
 - (void)setPropKeysManagedByAnimated_DO_NOT_USE_THIS_IS_BROKEN:(nullable NSSet<NSString *> *)props;
 - (nullable NSSet<NSString *> *)propKeysManagedByAnimated_DO_NOT_USE_THIS_IS_BROKEN;
 
diff --git a/React/Fabric/Mounting/UIView+ComponentViewProtocol.mm b/React/Fabric/Mounting/UIView+ComponentViewProtocol.mm
index c10dfbc8654..939faead8dc 100644
--- a/React/Fabric/Mounting/UIView+ComponentViewProtocol.mm
+++ b/React/Fabric/Mounting/UIView+ComponentViewProtocol.mm
@@ -132,6 +132,17 @@ using namespace facebook::react;
   return nullptr;
 }
 
+- (BOOL)isJSResponder
+{
+  // Default implementation always returns `NO`.
+  return NO;
+}
+
+- (void)setIsJSResponder:(BOOL)isJSResponder
+{
+  // Default implementation does nothing.
+}
+
 - (void)setPropKeysManagedByAnimated_DO_NOT_USE_THIS_IS_BROKEN:(nullable NSSet<NSString *> *)propKeys
 {
   // Default implementation does nothing.
diff --git a/React/Fabric/RCTScheduler.h b/React/Fabric/RCTScheduler.h
index d68a01e47c0..55670daca64 100644
--- a/React/Fabric/RCTScheduler.h
+++ b/React/Fabric/RCTScheduler.h
@@ -34,6 +34,8 @@ NS_ASSUME_NONNULL_BEGIN
 - (void)schedulerDidSendAccessibilityEvent:(facebook::react::ShadowView const &)shadowView
                                  eventType:(std::string const &)eventType;
 
+- (void)schedulerDidSetIsJSResponder:(BOOL)isJSResponder forShadowView:(facebook::react::ShadowView const &)shadowView;
+
 @end
 
 /**
diff --git a/React/Fabric/RCTScheduler.mm b/React/Fabric/RCTScheduler.mm
index bac276ca040..3e7281be63c 100644
--- a/React/Fabric/RCTScheduler.mm
+++ b/React/Fabric/RCTScheduler.mm
@@ -45,18 +45,10 @@ class SchedulerDelegateProxy : public SchedulerDelegate {
     [scheduler.delegate schedulerDidDispatchCommand:shadowView commandName:commandName args:args];
   }
 
-  void schedulerDidSetJSResponder(
-      SurfaceId surfaceId,
-      const ShadowView &shadowView,
-      const ShadowView &initialShadowView,
-      bool blockNativeResponder) override
+  void schedulerDidSetIsJSResponder(ShadowView const &shadowView, bool isJSResponder) override
   {
-    // Does nothing for now.
-  }
-
-  void schedulerDidClearJSResponder() override
-  {
-    // Does nothing for now.
+    RCTScheduler *scheduler = (__bridge RCTScheduler *)scheduler_;
+    [scheduler.delegate schedulerDidSetIsJSResponder:isJSResponder forShadowView:shadowView];
   }
 
   void schedulerDidSendAccessibilityEvent(const ShadowView &shadowView, std::string const &eventType) override
diff --git a/React/Fabric/RCTSurfacePresenter.mm b/React/Fabric/RCTSurfacePresenter.mm
index 7c752ad7703..e982243d62e 100644
--- a/React/Fabric/RCTSurfacePresenter.mm
+++ b/React/Fabric/RCTSurfacePresenter.mm
@@ -467,6 +467,11 @@ static BackgroundExecutor RCTGetBackgroundExecutor()
   [self->_mountingManager sendAccessibilityEvent:tag eventType:eventTypeStr];
 }
 
+- (void)schedulerDidSetIsJSResponder:(BOOL)isJSResponder forShadowView:(facebook::react::ShadowView const &)shadowView;
+{
+  [self->_mountingManager setIsJSResponder:isJSResponder forShadowView:shadowView];
+}
+
 - (void)addObserver:(id<RCTSurfacePresenterObserver>)observer
 {
   std::unique_lock<better::shared_mutex> lock(_observerListMutex);
diff --git a/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.cpp b/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.cpp
index 181250e0cd9..5d4ff6ae297 100644
--- a/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.cpp
+++ b/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.cpp
@@ -1106,11 +1106,9 @@ void Binding::schedulerDidSendAccessibilityEvent(
       eventTypeStr.get());
 }
 
-void Binding::schedulerDidSetJSResponder(
-    SurfaceId surfaceId,
-    const ShadowView &shadowView,
-    const ShadowView &initialShadowView,
-    bool blockNativeResponder) {
+void Binding::schedulerDidSetIsJSResponder(
+    ShadowView const &shadowView,
+    bool isJSResponder) {
   jni::global_ref<jobject> localJavaUIManager = getJavaUIManager();
   if (!localJavaUIManager) {
     LOG(ERROR) << "Binding::schedulerSetJSResponder: JavaUIManager disappeared";
@@ -1121,27 +1119,24 @@ void Binding::schedulerDidSetJSResponder(
       jni::findClassStatic(Binding::UIManagerJavaDescriptor)
           ->getMethod<void(jint, jint, jint, jboolean)>("setJSResponder");
 
-  setJSResponder(
-      localJavaUIManager,
-      shadowView.surfaceId,
-      shadowView.tag,
-      initialShadowView.tag,
-      (jboolean)blockNativeResponder);
-}
-
-void Binding::schedulerDidClearJSResponder() {
-  jni::global_ref<jobject> localJavaUIManager = getJavaUIManager();
-  if (!localJavaUIManager) {
-    LOG(ERROR)
-        << "Binding::schedulerClearJSResponder: JavaUIManager disappeared";
-    return;
-  }
-
   static auto clearJSResponder =
       jni::findClassStatic(Binding::UIManagerJavaDescriptor)
           ->getMethod<void()>("clearJSResponder");
 
-  clearJSResponder(localJavaUIManager);
+  if (isJSResponder) {
+    setJSResponder(
+        localJavaUIManager,
+        shadowView.surfaceId,
+        shadowView.tag,
+        // The closest non-flattened ancestor of the same value if the node is
+        // not flattened. For now, we don't support the case when the node can
+        // be flattened because the only component that uses this feature -
+        // ScrollView - cannot be flattened.
+        shadowView.tag,
+        (jboolean) true);
+  } else {
+    clearJSResponder(localJavaUIManager);
+  }
 }
 
 void Binding::registerNatives() {
diff --git a/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.h b/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.h
index f2ac6cd479a..23ce763dc1b 100644
--- a/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.h
+++ b/ReactAndroid/src/main/java/com/facebook/react/fabric/jni/Binding.h
@@ -140,13 +140,9 @@ class Binding : public jni::HybridClass<Binding>,
       const ShadowView &shadowView,
       std::string const &eventType) override;
 
-  void schedulerDidSetJSResponder(
-      SurfaceId surfaceId,
-      const ShadowView &shadowView,
-      const ShadowView &initialShadowView,
-      bool blockNativeResponder) override;
-
-  void schedulerDidClearJSResponder() override;
+  void schedulerDidSetIsJSResponder(
+      ShadowView const &shadowView,
+      bool isJSResponder) override;
 
   void setPixelDensity(float pointScaleFactor);
 
diff --git a/ReactCommon/react/renderer/scheduler/Scheduler.cpp b/ReactCommon/react/renderer/scheduler/Scheduler.cpp
index 3ca4efb45a0..026052ce5ac 100644
--- a/ReactCommon/react/renderer/scheduler/Scheduler.cpp
+++ b/ReactCommon/react/renderer/scheduler/Scheduler.cpp
@@ -423,27 +423,14 @@ void Scheduler::uiManagerDidSendAccessibilityEvent(
 }
 
 /*
- * Set JS responder for a view
+ * Set JS responder for a view.
  */
-void Scheduler::uiManagerDidSetJSResponder(
-    SurfaceId surfaceId,
-    const ShadowNode::Shared &shadowNode,
-    bool blockNativeResponder) {
+void Scheduler::uiManagerDidSetIsJSResponder(
+    ShadowNode::Shared const &shadowNode,
+    bool isJSResponder) {
   if (delegate_) {
-    // TODO: the first shadowView paramenter, should be the first parent that
-    // is non virtual.
-    auto shadowView = ShadowView(*shadowNode);
-    delegate_->schedulerDidSetJSResponder(
-        surfaceId, shadowView, shadowView, blockNativeResponder);
-  }
-}
-
-/*
- * Clear the JSResponder for a view
- */
-void Scheduler::uiManagerDidClearJSResponder() {
-  if (delegate_) {
-    delegate_->schedulerDidClearJSResponder();
+    delegate_->schedulerDidSetIsJSResponder(
+        ShadowView(*shadowNode), isJSResponder);
   }
 }
 
diff --git a/ReactCommon/react/renderer/scheduler/Scheduler.h b/ReactCommon/react/renderer/scheduler/Scheduler.h
index 9f75805ac70..8e0c8db0c5a 100644
--- a/ReactCommon/react/renderer/scheduler/Scheduler.h
+++ b/ReactCommon/react/renderer/scheduler/Scheduler.h
@@ -122,11 +122,9 @@ class Scheduler final : public UIManagerDelegate {
   void uiManagerDidSendAccessibilityEvent(
       const ShadowNode::Shared &shadowNode,
       std::string const &eventType) override;
-  void uiManagerDidSetJSResponder(
-      SurfaceId surfaceId,
-      const ShadowNode::Shared &shadowView,
-      bool blockNativeResponder) override;
-  void uiManagerDidClearJSResponder() override;
+  void uiManagerDidSetIsJSResponder(
+      ShadowNode::Shared const &shadowView,
+      bool isJSResponder) override;
 
  private:
   friend class SurfaceHandler;
diff --git a/ReactCommon/react/renderer/scheduler/SchedulerDelegate.h b/ReactCommon/react/renderer/scheduler/SchedulerDelegate.h
index dabe3638b98..726e7ef937a 100644
--- a/ReactCommon/react/renderer/scheduler/SchedulerDelegate.h
+++ b/ReactCommon/react/renderer/scheduler/SchedulerDelegate.h
@@ -48,16 +48,9 @@ class SchedulerDelegate {
   /*
    * Set JS responder for a view
    */
-  virtual void schedulerDidSetJSResponder(
-      SurfaceId surfaceId,
-      const ShadowView &shadowView,
-      const ShadowView &initialShadowView,
-      bool blockNativeResponder) = 0;
-
-  /*
-   * Clear the JSResponder for a view
-   */
-  virtual void schedulerDidClearJSResponder() = 0;
+  virtual void schedulerDidSetIsJSResponder(
+      ShadowView const &shadowView,
+      bool isJSResponder) = 0;
 
   virtual ~SchedulerDelegate() noexcept = default;
 };
diff --git a/ReactCommon/react/renderer/uimanager/UIManager.cpp b/ReactCommon/react/renderer/uimanager/UIManager.cpp
index 6b31bf8e990..f13f0e76909 100644
--- a/ReactCommon/react/renderer/uimanager/UIManager.cpp
+++ b/ReactCommon/react/renderer/uimanager/UIManager.cpp
@@ -112,18 +112,11 @@ void UIManager::completeSurface(
   });
 }
 
-void UIManager::setJSResponder(
-    const ShadowNode::Shared &shadowNode,
-    const bool blockNativeResponder) const {
+void UIManager::setIsJSResponder(
+    ShadowNode::Shared const &shadowNode,
+    bool isJSResponder) const {
   if (delegate_) {
-    delegate_->uiManagerDidSetJSResponder(
-        shadowNode->getSurfaceId(), shadowNode, blockNativeResponder);
-  }
-}
-
-void UIManager::clearJSResponder() const {
-  if (delegate_) {
-    delegate_->uiManagerDidClearJSResponder();
+    delegate_->uiManagerDidSetIsJSResponder(shadowNode, isJSResponder);
   }
 }
 
diff --git a/ReactCommon/react/renderer/uimanager/UIManager.h b/ReactCommon/react/renderer/uimanager/UIManager.h
index 6dc8a44f968..36f15fa8815 100644
--- a/ReactCommon/react/renderer/uimanager/UIManager.h
+++ b/ReactCommon/react/renderer/uimanager/UIManager.h
@@ -129,11 +129,9 @@ class UIManager final : public ShadowTreeDelegate {
       SharedShadowNodeUnsharedList const &rootChildren,
       ShadowTree::CommitOptions commitOptions) const;
 
-  void setJSResponder(
-      const ShadowNode::Shared &shadowNode,
-      const bool blockNativeResponder) const;
-
-  void clearJSResponder() const;
+  void setIsJSResponder(
+      ShadowNode::Shared const &shadowNode,
+      bool isJSResponder) const;
 
   ShadowNode::Shared findNodeAtPoint(
       ShadowNode::Shared const &shadowNode,
diff --git a/ReactCommon/react/renderer/uimanager/UIManagerBinding.cpp b/ReactCommon/react/renderer/uimanager/UIManagerBinding.cpp
index 3dc2495bf7f..59fe6908618 100644
--- a/ReactCommon/react/renderer/uimanager/UIManagerBinding.cpp
+++ b/ReactCommon/react/renderer/uimanager/UIManagerBinding.cpp
@@ -263,7 +263,7 @@ jsi::Value UIManagerBinding::get(
         });
   }
 
-  if (methodName == "setJSResponder") {
+  if (methodName == "setIsJSResponder") {
     return jsi::Function::createFromHostFunction(
         runtime,
         name,
@@ -273,7 +273,7 @@ jsi::Value UIManagerBinding::get(
             jsi::Value const &thisValue,
             jsi::Value const *arguments,
             size_t count) noexcept -> jsi::Value {
-          uiManager->setJSResponder(
+          uiManager->setIsJSResponder(
               shadowNodeFromValue(runtime, arguments[0]),
               arguments[1].getBool());
 
@@ -311,22 +311,6 @@ jsi::Value UIManagerBinding::get(
         });
   }
 
-  if (methodName == "clearJSResponder") {
-    return jsi::Function::createFromHostFunction(
-        runtime,
-        name,
-        0,
-        [uiManager](
-            jsi::Runtime &runtime,
-            jsi::Value const &thisValue,
-            jsi::Value const *arguments,
-            size_t count) noexcept -> jsi::Value {
-          uiManager->clearJSResponder();
-
-          return jsi::Value::undefined();
-        });
-  }
-
   // Semantic: Clones the node with *same* props and *empty* children.
   if (methodName == "cloneNodeWithNewChildren") {
     return jsi::Function::createFromHostFunction(
diff --git a/ReactCommon/react/renderer/uimanager/UIManagerDelegate.h b/ReactCommon/react/renderer/uimanager/UIManagerDelegate.h
index 5062158f60d..5e993056c42 100644
--- a/ReactCommon/react/renderer/uimanager/UIManagerDelegate.h
+++ b/ReactCommon/react/renderer/uimanager/UIManagerDelegate.h
@@ -52,17 +52,11 @@ class UIManagerDelegate {
       std::string const &eventType) = 0;
 
   /*
-   * Set JS responder for a view
+   * Set JS responder for a view.
    */
-  virtual void uiManagerDidSetJSResponder(
-      SurfaceId surfaceId,
-      ShadowNode::Shared const &shadowView,
-      bool blockNativeResponder) = 0;
-
-  /*
-   * Clear the JSResponder for a view
-   */
-  virtual void uiManagerDidClearJSResponder() = 0;
+  virtual void uiManagerDidSetIsJSResponder(
+      ShadowNode::Shared const &shadowNode,
+      bool isJSResponder) = 0;
 
   virtual ~UIManagerDelegate() noexcept = default;
 };
diff --git a/ReactCommon/react/renderer/uimanager/primitives.h b/ReactCommon/react/renderer/uimanager/primitives.h
index 9fb2ea92786..a87deeaa4bc 100644
--- a/ReactCommon/react/renderer/uimanager/primitives.h
+++ b/ReactCommon/react/renderer/uimanager/primitives.h
@@ -43,6 +43,10 @@ struct ShadowNodeListWrapper : public jsi::HostObject {
 inline static ShadowNode::Shared shadowNodeFromValue(
     jsi::Runtime &runtime,
     jsi::Value const &value) {
+  if (value.isNull()) {
+    return nullptr;
+  }
+
   return value.getObject(runtime)
       .getHostObject<ShadowNodeWrapper>(runtime)
       ->shadowNode;