diff --git a/packages/react-native/ReactCommon/jsinspector-modern/InspectorFlags.cpp b/packages/react-native/ReactCommon/jsinspector-modern/InspectorFlags.cpp
index d71944064e5..f43ff1d4215 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/InspectorFlags.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/InspectorFlags.cpp
@@ -39,10 +39,9 @@ const InspectorFlags::Values& InspectorFlags::loadFlagsAndAssertUnchanged()
           true,
 #elif defined(REACT_NATIVE_FORCE_DISABLE_FUSEBOX)
           false,
-#elif defined(HERMES_ENABLE_DEBUGGER) && \
-    defined(REACT_NATIVE_ENABLE_FUSEBOX_DEBUG)
+#elif !defined(NDEBUG) && defined(REACT_NATIVE_ENABLE_FUSEBOX_DEBUG)
           true,
-#elif defined(HERMES_ENABLE_DEBUGGER)
+#elif !defined(NDEBUG)
           ReactNativeFeatureFlags::fuseboxEnabledDebug(),
 #else
           ReactNativeFeatureFlags::fuseboxEnabledRelease(),