diff --git a/React/Base/RCTDefines.h b/React/Base/RCTDefines.h
index 564ae996ca1..68fa8422815 100644
--- a/React/Base/RCTDefines.h
+++ b/React/Base/RCTDefines.h
@@ -46,6 +46,43 @@
 #endif
 #endif
 
+/**
+ * RCT_REMOTE_PROFILE: RCT_PROFILE + RCT_ENABLE_INSPECTOR + enable the
+ * connectivity functionality to control the profiler remotely, such as via Chrome DevTools or
+ * Flipper.
+ */
+#ifndef RCT_REMOTE_PROFILE
+#define RCT_REMOTE_PROFILE RCT_DEV
+#endif
+
+/**
+ * Enable the code to support making calls to the underlying sampling profiler mechanism.
+ */
+#ifndef RCT_PROFILE
+#define RCT_PROFILE RCT_REMOTE_PROFILE
+#endif
+
+#ifndef RCT_ENABLE_INSPECTOR
+#if (RCT_DEV || RCT_REMOTE_PROFILE) && __has_include(<React/RCTInspectorDevServerHelper.h>)
+#define RCT_ENABLE_INSPECTOR 1
+#else
+#define RCT_ENABLE_INSPECTOR 0
+#endif
+#endif
+
+/**
+ * Sanity check that these compile-time flags are compatible. RCT_REMOTE_PROFILE requires RCT_PROFILE and
+ * RCT_ENABLE_INSPECTOR
+ */
+#if RCT_REMOTE_PROFILE
+#if !RCT_PROFILE
+#error "RCT_PROFILE needs to be set to fulfill RCT_REMOTE_PROFILE"
+#endif // RCT_PROFILE
+#if !RCT_ENABLE_INSPECTOR
+#error "RCT_ENABLE_INSPECTOR needs to be set to fulfill RCT_REMOTE_PROFILE"
+#endif // RCT_ENABLE_INSPECTOR
+#endif // RCT_REMOTE_PROFILE
+
 /**
  * RCT_DEV_MENU can be used to toggle the dev menu separately from RCT_DEV.
  * By default though, it will inherit from RCT_DEV.
@@ -63,14 +100,6 @@
 #define RCT_ENABLE_LOADING_FROM_PACKAGER RCT_DEV_MENU
 #endif
 
-#ifndef RCT_ENABLE_INSPECTOR
-#if RCT_DEV && __has_include(<React/RCTInspectorDevServerHelper.h>)
-#define RCT_ENABLE_INSPECTOR 1
-#else
-#define RCT_ENABLE_INSPECTOR 0
-#endif
-#endif
-
 #ifndef RCT_DEV_SETTINGS_ENABLE_PACKAGER_CONNECTION
 #if RCT_DEV && (__has_include("RCTPackagerConnection.h") || __has_include(<React/RCTPackagerConnection.h>))
 #define RCT_DEV_SETTINGS_ENABLE_PACKAGER_CONNECTION 1
diff --git a/React/CoreModules/RCTDevSettings.mm b/React/CoreModules/RCTDevSettings.mm
index ceda9c55a37..e243eb0e0ad 100644
--- a/React/CoreModules/RCTDevSettings.mm
+++ b/React/CoreModules/RCTDevSettings.mm
@@ -53,7 +53,7 @@ void RCTDevSettingsSetEnabled(BOOL enabled)
   devSettingsMenuEnabled = enabled;
 }
 
-#if RCT_DEV_MENU
+#if RCT_DEV_MENU || RCT_REMOTE_PROFILE
 
 @interface RCTDevSettingsUserDefaultsDataSource : NSObject <RCTDevSettingsDataSource>
 
@@ -618,7 +618,9 @@ RCT_EXPORT_METHOD(addMenuItem : (NSString *)title)
 
 - (RCTDevSettings *)devSettings
 {
-#if RCT_DEV_MENU
+#if RCT_REMOTE_PROFILE
+  return [self moduleForClass:[RCTDevSettings class]];
+#elif RCT_DEV_MENU
   return devSettingsMenuEnabled ? [self moduleForClass:[RCTDevSettings class]] : nil;
 #else
   return nil;
diff --git a/React/DevSupport/RCTInspectorDevServerHelper.h b/React/DevSupport/RCTInspectorDevServerHelper.h
index f527f50a1a2..08397c36ab0 100644
--- a/React/DevSupport/RCTInspectorDevServerHelper.h
+++ b/React/DevSupport/RCTInspectorDevServerHelper.h
@@ -11,7 +11,7 @@
 #import <React/RCTDefines.h>
 #import <React/RCTInspectorPackagerConnection.h>
 
-#if RCT_DEV
+#if RCT_DEV || RCT_REMOTE_PROFILE
 
 @interface RCTInspectorDevServerHelper : NSObject
 
diff --git a/React/DevSupport/RCTInspectorDevServerHelper.mm b/React/DevSupport/RCTInspectorDevServerHelper.mm
index 687297d8c46..cf404f3900c 100644
--- a/React/DevSupport/RCTInspectorDevServerHelper.mm
+++ b/React/DevSupport/RCTInspectorDevServerHelper.mm
@@ -7,7 +7,7 @@
 
 #import <React/RCTInspectorDevServerHelper.h>
 
-#if RCT_DEV
+#if RCT_DEV || RCT_REMOTE_PROFILE
 
 #import <React/RCTLog.h>
 #import <UIKit/UIKit.h>
diff --git a/React/Inspector/RCTInspector.h b/React/Inspector/RCTInspector.h
index 49acfcd7224..8738c9b7900 100644
--- a/React/Inspector/RCTInspector.h
+++ b/React/Inspector/RCTInspector.h
@@ -8,7 +8,7 @@
 #import <Foundation/Foundation.h>
 #import <React/RCTDefines.h>
 
-#if RCT_DEV
+#if RCT_DEV || RCT_REMOTE_PROFILE
 
 @class RCTInspectorRemoteConnection;
 
diff --git a/React/Inspector/RCTInspector.mm b/React/Inspector/RCTInspector.mm
index ff1c007dd09..4e31ecbb180 100644
--- a/React/Inspector/RCTInspector.mm
+++ b/React/Inspector/RCTInspector.mm
@@ -7,7 +7,7 @@
 
 #import <React/RCTInspector.h>
 
-#if RCT_DEV
+#if RCT_DEV || RCT_REMOTE_PROFILE
 
 #include <jsinspector/InspectorInterfaces.h>
 
diff --git a/React/Inspector/RCTInspectorPackagerConnection.h b/React/Inspector/RCTInspectorPackagerConnection.h
index 184b05d5970..96bb8416b77 100644
--- a/React/Inspector/RCTInspectorPackagerConnection.h
+++ b/React/Inspector/RCTInspectorPackagerConnection.h
@@ -8,7 +8,7 @@
 #import <Foundation/Foundation.h>
 #import <React/RCTDefines.h>
 
-#if RCT_DEV
+#if RCT_DEV || RCT_REMOTE_PROFILE
 
 @interface RCTBundleStatus : NSObject
 @property (atomic, assign) BOOL isLastBundleDownloadSuccess;
diff --git a/React/Inspector/RCTInspectorPackagerConnection.m b/React/Inspector/RCTInspectorPackagerConnection.m
index 532c2d9c78b..af5c223e474 100644
--- a/React/Inspector/RCTInspectorPackagerConnection.m
+++ b/React/Inspector/RCTInspectorPackagerConnection.m
@@ -7,7 +7,7 @@
 
 #import <React/RCTInspectorPackagerConnection.h>
 
-#if RCT_DEV
+#if RCT_DEV || RCT_REMOTE_PROFILE
 
 #import <React/RCTDefines.h>
 #import <React/RCTInspector.h>