diff --git a/.github/workflows/prebuild-ios.yml b/.github/workflows/prebuild-ios.yml
index e2bf4b0b346..dd43f7762ff 100644
--- a/.github/workflows/prebuild-ios.yml
+++ b/.github/workflows/prebuild-ios.yml
@@ -43,3 +43,71 @@ jobs:
           key: v1-ios-dependencies-${{ hashfiles('scripts/releases/ios-prebuilds/configuration.js') }}
           enableCrossOsArchive: true
           path: packages/react-native/third-party/
+
+  build-apple-slices:
+    name: Build Apple Slice
+    runs-on: macos-14
+    needs: [prepare_workspace]
+    strategy:
+      fail-fast: false
+      matrix:
+        flavor: ['Debug', 'Release']
+        slice: ['ios',
+                'ios-simulator',
+                'macos',
+                'mac-catalyst',
+                'tvos',
+                'tvos-simulator',
+                'xros',
+                'xros-simulator']
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v4
+      - name: Setup node.js
+        uses: ./.github/actions/setup-node
+      - name: Setup xcode
+        uses: ./.github/actions/setup-xcode
+        with:
+          xcode-version: '16.1'
+      - name: Restore slice folder
+        id: restore-slice-folder
+        uses: actions/cache/restore@v4
+        with:
+          path: packages/react-native/third-party/.build/Build/Products
+          key: v1-ios-dependencies-slice-folder-${{ matrix.slice }}-${{ matrix.flavor }}-${{ hashfiles('scripts/releases/ios-prebuilds/configuration.js') }}
+      - name: Yarn Install
+        if: steps.restore-slice-folder.outputs.cache-hit != 'true'
+        uses: ./.github/actions/yarn-install
+      - name: Restore workspace
+        if: steps.restore-slice-folder.outputs.cache-hit != 'true'
+        uses: actions/download-artifact@v4
+        with:
+          name: ios-prebuilds-workspace
+          path: packages/react-native/third-party/
+      - name: Print third-party folder structure
+        run: ls -lR packages/react-native/third-party
+      - name: Install VisionOS
+        if: ${{ steps.restore-slice-folder.outputs.cache-hit != 'true' && (matrix.slice == 'xros' || matrix.slice == 'xros-simulator') }}
+        run: |
+          # https://github.com/actions/runner-images/issues/10559
+          sudo xcodebuild -runFirstLaunch
+          sudo xcrun simctl list
+          sudo xcodebuild -downloadPlatform visionOS
+          sudo xcodebuild -runFirstLaunch
+      - name: Build slice ${{ matrix.slice }} for ${{ matrix.flavor }}
+        if: steps.restore-slice-folder.outputs.cache-hit != 'true'
+        run:  node scripts/releases/prepare-ios-prebuilds.js -b -p ${{ matrix.slice }} -r ${{ matrix.flavor }}
+      - name: Upload Artifacts
+        uses: actions/upload-artifact@v4.3.4
+        with:
+          name: ios-slice-${{ matrix.flavor }}-${{ matrix.slice }}
+          path: |
+            packages/react-native/third-party/.build/Build/Products
+      - name: Save Cache
+        uses: actions/cache/save@v4
+        if: ${{ github.ref == 'refs/heads/main' }} # To avoid that the cache explode
+        with:
+          key: v1-ios-dependencies-slice-folder-${{ matrix.slice }}-${{ matrix.flavor }}-${{ hashfiles('scripts/releases/ios-prebuilds/configuration.js') }}
+          enableCrossOsArchive: true
+          path: |
+            packages/react-native/third-party/.build/Build/Products
diff --git a/scripts/releases/ios-prebuild/build.js b/scripts/releases/ios-prebuild/build.js
index 288eb37ceee..96a6fdf4826 100644
--- a/scripts/releases/ios-prebuild/build.js
+++ b/scripts/releases/ios-prebuild/build.js
@@ -16,7 +16,7 @@ const fs = require('fs');
 const path = require('path');
 
 /*::
-import type { Dependency, Platform } from './types';
+import type { Dependency, Destination, Platform } from './types';
 */
 
 /**
@@ -28,15 +28,21 @@ async function buildDepenencies(
   scheme /*: string */,
   configuration /*: string */,
   dependencies /*: $ReadOnlyArray<Dependency> */,
-  platforms /*: $ReadOnlyArray<Platform> */,
+  destinations /*: $ReadOnlyArray<Destination> */,
   rootFolder /*: string */,
   buildFolder /*: string */,
 ) {
   console.log('✅ Building dependencies...');
 
   await Promise.all(
-    platforms.map(platform =>
-      buildPlatform(scheme, configuration, platform, rootFolder, buildFolder),
+    destinations.map(destination =>
+      buildPlatform(
+        scheme,
+        configuration,
+        destination,
+        rootFolder,
+        buildFolder,
+      ),
     ),
   );
 
@@ -50,13 +56,13 @@ async function buildDepenencies(
 async function buildPlatform(
   scheme /*: string */,
   configuration /*: string */,
-  platform /*: Platform */,
+  destination /*: Destination */,
   rootFolder /*: string */,
   buildFolder /*: string */,
 ) {
-  console.log(`Building ${platform}...`);
+  console.log(`Building ${destination}...`);
   const command =
-    `xcodebuild -scheme "${scheme}" -destination "generic/platform=${platform}" ` +
+    `xcodebuild -scheme "${scheme}" -destination "generic/platform=${destination}" ` +
     `-derivedDataPath "${buildFolder}" ` +
     `-configuration "${configuration}" ` +
     'SKIP_INSTALL=NO \
diff --git a/scripts/releases/ios-prebuild/cli.js b/scripts/releases/ios-prebuild/cli.js
index 5cc36865b8b..f01007ed17e 100644
--- a/scripts/releases/ios-prebuild/cli.js
+++ b/scripts/releases/ios-prebuild/cli.js
@@ -13,9 +13,22 @@ const {dependencies, platforms} = require('./configuration');
 const yargs = require('yargs');
 
 /*::
-import type {Dependency, Platform} from './types';
+import type {Dependency, Destination, Platform} from './types';
 */
 
+// CI can't use commas in cache keys, so 'macOS,variant=Mac Catalyst' was creating troubles
+// This map that converts from platforms to valid Xcodebuild destinations.
+const platformToDestination /*: $ReadOnly<{|[Platform]: Destination|}> */ = {
+  ios: 'iOS',
+  'ios-simulator': 'iOS Simulator',
+  macos: 'macOS',
+  'mac-catalyst': 'macOS,variant=Mac Catalyst',
+  tvos: 'tvOS',
+  'tvos-simulator': 'tvOS Simulator',
+  xros: 'visionOS',
+  'xros-simulator': 'visionOS Simulator',
+};
+
 const arrayLike = (value /*: Array<any> */) /*: Array<any> */ =>
   Array.isArray(value) ? value : [value];
 
@@ -74,7 +87,7 @@ async function getCLIConfiguration() /*: Promise<?{|
     build: boolean,
     compose: boolean,
   |},
-  platforms: $ReadOnlyArray<Platform>,
+  destinations: $ReadOnlyArray<Destination>,
   dependencies: $ReadOnlyArray<Dependency>,
   configuration: string,
 |}> */ {
@@ -102,7 +115,9 @@ async function getCLIConfiguration() /*: Promise<?{|
   }
 
   // Prepare platforms and dependencies
-  const resolvedPlatforms = platforms.filter(p => argv.platforms.includes(p));
+  const resolvedPlatforms = platforms
+    .filter(p => argv.platforms.includes(p))
+    .map(p => platformToDestination[p]);
   const resolvedDependencies = dependencies.filter(d =>
     argv.dependencies.includes(d.name),
   );
@@ -121,7 +136,7 @@ async function getCLIConfiguration() /*: Promise<?{|
       build: runAllCommands || argv.build != null,
       compose: runAllCommands || argv.compose != null,
     },
-    platforms: resolvedPlatforms,
+    destinations: resolvedPlatforms,
     dependencies: resolvedDependencies,
     configuration: argv.configuration,
   };
diff --git a/scripts/releases/ios-prebuild/configuration.js b/scripts/releases/ios-prebuild/configuration.js
index 56a834add23..d306d44f2a6 100644
--- a/scripts/releases/ios-prebuild/configuration.js
+++ b/scripts/releases/ios-prebuild/configuration.js
@@ -14,14 +14,14 @@ import type { Dependency, Platform } from './types';
 */
 
 const platforms /*: $ReadOnlyArray<Platform> */ = [
-  'iOS',
-  'iOS Simulator',
-  'macOS',
-  'macOS,variant=Mac Catalyst',
-  'tvOS',
-  'tvOS Simulator',
-  'visionOS',
-  'visionOS Simulator',
+  'ios',
+  'ios-simulator',
+  'macos',
+  'mac-catalyst',
+  'tvos',
+  'tvos-simulator',
+  'xros',
+  'xros-simulator',
 ];
 
 const CPP_STANDARD = 'c++20';
diff --git a/scripts/releases/ios-prebuild/types.js b/scripts/releases/ios-prebuild/types.js
index 7e86ff60046..2d842afca77 100644
--- a/scripts/releases/ios-prebuild/types.js
+++ b/scripts/releases/ios-prebuild/types.js
@@ -49,13 +49,23 @@ export type Dependency = $ReadOnly<{
 }>;
 
 export type Platform =
+  'ios' |
+  'ios-simulator' |
+  'macos' |
+  'mac-catalyst' |
+  'tvos' |
+  'tvos-simulator' |
+  'xros' |
+  'xros-simulator';
+
+export type Destination =
   'iOS' |
-  'iOS Simulator' |
-  'macOS' |
+  'iOS Simulator' |
+  'macOS' |
   'macOS,variant=Mac Catalyst' |
   'tvOS' |
   'tvOS Simulator' |
-  'visionOS' |
+  'visionOS' |
   'visionOS Simulator';
 */
 
diff --git a/scripts/releases/prepare-ios-prebuilds.js b/scripts/releases/prepare-ios-prebuilds.js
index e249af454bc..cfc716e56c7 100644
--- a/scripts/releases/prepare-ios-prebuilds.js
+++ b/scripts/releases/prepare-ios-prebuilds.js
@@ -52,7 +52,7 @@ async function main() {
       SCHEME,
       cli.configuration,
       cli.dependencies,
-      cli.platforms,
+      cli.destinations,
       rootFolder,
       buildFolder,
     );