diff --git a/packages/react-native/src/private/webapis/performance/PerformanceObserver.js b/packages/react-native/src/private/webapis/performance/PerformanceObserver.js
index 980fd2d55aa..a31edf4a353 100644
--- a/packages/react-native/src/private/webapis/performance/PerformanceObserver.js
+++ b/packages/react-native/src/private/webapis/performance/PerformanceObserver.js
@@ -100,11 +100,17 @@ const onPerformanceEntry = () => {
       const durationThreshold = observerConfig.entryTypes.get(entry.entryType);
       return entry.duration >= (durationThreshold ?? 0);
     });
-    observerConfig.callback(
-      new PerformanceObserverEntryList(entriesForObserver),
-      observer,
-      droppedEntriesCount,
-    );
+    if (entriesForObserver.length !== 0) {
+      try {
+        observerConfig.callback(
+          new PerformanceObserverEntryList(entriesForObserver),
+          observer,
+          droppedEntriesCount,
+        );
+      } catch (error) {
+        console.error(error);
+      }
+    }
   }
 };
 
diff --git a/packages/react-native/src/private/webapis/performance/__tests__/PerformanceObserver-test.js b/packages/react-native/src/private/webapis/performance/__tests__/PerformanceObserver-test.js
index cf46dcbfd0e..06cfbff59cd 100644
--- a/packages/react-native/src/private/webapis/performance/__tests__/PerformanceObserver-test.js
+++ b/packages/react-native/src/private/webapis/performance/__tests__/PerformanceObserver-test.js
@@ -205,4 +205,58 @@ describe('PerformanceObserver', () => {
       'mark7',
     ]);
   });
+
+  it('should guard against errors in observer callbacks', () => {
+    jest.spyOn(console, 'error').mockImplementation(() => {});
+
+    const observer1Callback = jest.fn(() => {
+      throw new Error('observer 1 callback');
+    });
+    const observer1 = new PerformanceObserver(observer1Callback);
+
+    const observer2Callback = jest.fn();
+    const observer2 = new PerformanceObserver(observer2Callback);
+
+    observer1.observe({type: 'mark'});
+    observer2.observe({type: 'mark'});
+
+    NativePerformanceObserver.logRawEntry({
+      name: 'mark1',
+      entryType: RawPerformanceEntryTypeValues.MARK,
+      startTime: 0,
+      duration: 200,
+    });
+
+    jest.runAllTicks();
+
+    expect(observer1Callback).toHaveBeenCalled();
+    expect(observer2Callback).toHaveBeenCalled();
+
+    expect(console.error).toHaveBeenCalledWith(
+      new Error('observer 1 callback'),
+    );
+  });
+
+  it('should not invoke observers with non-matching entries', () => {
+    const observer1Callback = jest.fn();
+    const observer1 = new PerformanceObserver(observer1Callback);
+
+    const observer2Callback = jest.fn();
+    const observer2 = new PerformanceObserver(observer2Callback);
+
+    observer1.observe({type: 'mark'});
+    observer2.observe({type: 'measure'});
+
+    NativePerformanceObserver.logRawEntry({
+      name: 'mark1',
+      entryType: RawPerformanceEntryTypeValues.MARK,
+      startTime: 0,
+      duration: 200,
+    });
+
+    jest.runAllTicks();
+
+    expect(observer1Callback).toHaveBeenCalled();
+    expect(observer2Callback).not.toHaveBeenCalled();
+  });
 });