diff --git a/Libraries/Core/InitializeCore.js b/Libraries/Core/InitializeCore.js
index d1807071d03..8b9a6a49073 100644
--- a/Libraries/Core/InitializeCore.js
+++ b/Libraries/Core/InitializeCore.js
@@ -41,15 +41,6 @@ require('./setUpSegmentFetcher');
 if (__DEV__) {
   require('./checkNativeVersion');
   require('./setUpDeveloperTools');
-
-  // This is used by the require.js polyfill for hot reloading.
-  // TODO(t9759686) Scan polyfills for dependencies, too
-  const reload = require('../NativeModules/specs/NativeDevSettings').default
-    .reload;
-  if (typeof reload !== 'function') {
-    throw new Error('Could not find the reload() implementation.');
-  }
-  (require: any).reload = reload;
 }
 
 const GlobalPerformanceLogger = require('../Utilities/GlobalPerformanceLogger');
diff --git a/Libraries/Core/setUpDeveloperTools.js b/Libraries/Core/setUpDeveloperTools.js
index 43213cb94bb..66037c1553e 100644
--- a/Libraries/Core/setUpDeveloperTools.js
+++ b/Libraries/Core/setUpDeveloperTools.js
@@ -16,27 +16,39 @@ import Platform from '../Utilities/Platform';
  * You can use this module directly, or just require InitializeCore.
  */
 if (__DEV__) {
-  if (!global.__RCTProfileIsProfiling) {
-    // not when debugging in chrome
-    // TODO(t12832058) This check is broken
-    if (!window.document) {
-      require('./Devtools/setupDevtools');
+  // TODO (T45803484) Enable devtools for bridgeless RN
+  if (!global.RN$Bridgeless) {
+    if (!global.__RCTProfileIsProfiling) {
+      // not when debugging in chrome
+      // TODO(t12832058) This check is broken
+      if (!window.document) {
+        require('./Devtools/setupDevtools');
+      }
+
+      // Set up inspector
+      const JSInspector = require('../JSInspector/JSInspector');
+      JSInspector.registerAgent(require('../JSInspector/NetworkAgent'));
     }
 
-    // Set up inspector
-    const JSInspector = require('../JSInspector/JSInspector');
-    JSInspector.registerAgent(require('../JSInspector/NetworkAgent'));
-  }
+    if (!Platform.isTesting) {
+      const logToConsole = require('./Devtools/logToConsole');
+      ['log', 'warn', 'info', 'trace'].forEach(level => {
+        const originalFunction = console[level];
+        // $FlowFixMe Overwrite console methods
+        console[level] = function(...args) {
+          logToConsole(level, args);
+          originalFunction.apply(console, args);
+        };
+      });
+    }
 
-  if (!Platform.isTesting) {
-    const logToConsole = require('./Devtools/logToConsole');
-    ['log', 'warn', 'info', 'trace'].forEach(level => {
-      const originalFunction = console[level];
-      // $FlowFixMe Overwrite console methods
-      console[level] = function(...args) {
-        logToConsole(level, args);
-        originalFunction.apply(console, args);
-      };
-    });
+    // This is used by the require.js polyfill for hot reloading.
+    // TODO(t9759686) Scan polyfills for dependencies, too
+    const reload = require('../NativeModules/specs/NativeDevSettings').default
+      .reload;
+    if (typeof reload !== 'function') {
+      throw new Error('Could not find the reload() implementation.');
+    }
+    (require: any).reload = reload; // flowlint-line unclear-type: off
   }
 }