diff --git a/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp b/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp
index 36efb78e951..46c1a94df31 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp
@@ -129,6 +129,20 @@ void HostAgent::handleRequest(const cdp::PreparsedRequest& req) {
       sendFuseboxNotice();
     }
 
+    shouldSendOKResponse = true;
+    isFinishedHandlingRequest = true;
+  } else if (req.method == "ReactNativeApplication.enable") {
+    sessionState_.isReactNativeApplicationDomainEnabled = true;
+
+    frontendChannel_(cdp::jsonNotification(
+        "ReactNativeApplication.metadataUpdated",
+        hostMetadataToDynamic(hostMetadata_)));
+
+    shouldSendOKResponse = true;
+    isFinishedHandlingRequest = true;
+  } else if (req.method == "ReactNativeApplication.disable") {
+    sessionState_.isReactNativeApplicationDomainEnabled = false;
+
     shouldSendOKResponse = true;
     isFinishedHandlingRequest = true;
   } else if (req.method == "Tracing.start") {
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.cpp b/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.cpp
index 69cbf598a13..00810280c05 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.cpp
@@ -220,4 +220,12 @@ bool HostTargetController::decrementPauseOverlayCounter() {
   return true;
 }
 
+folly::dynamic hostMetadataToDynamic(const HostTargetMetadata& metadata) {
+  folly::dynamic result = folly::dynamic::object;
+
+  result["integrationName"] = metadata.integrationName.value_or(nullptr);
+
+  return result;
+}
+
 } // namespace facebook::react::jsinspector_modern
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.h b/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.h
index dc271e2e056..9fb5ab26f36 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.h
+++ b/packages/react-native/ReactCommon/jsinspector-modern/HostTarget.h
@@ -251,4 +251,6 @@ class JSINSPECTOR_EXPORT HostTarget
   friend class HostTargetController;
 };
 
+folly::dynamic hostMetadataToDynamic(const HostTargetMetadata& metadata);
+
 } // namespace facebook::react::jsinspector_modern
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h b/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h
index 36c4c72666f..28074ba4bd3 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h
+++ b/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h
@@ -22,6 +22,7 @@ struct SessionState {
   // TODO: Generalise this to arbitrary domains
   bool isDebuggerDomainEnabled{false};
   bool isLogDomainEnabled{false};
+  bool isReactNativeApplicationDomainEnabled{false};
   bool isRuntimeDomainEnabled{false};
 
   /**
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/tests/JsiIntegrationTest.cpp b/packages/react-native/ReactCommon/jsinspector-modern/tests/JsiIntegrationTest.cpp
index c357215339e..c83486375da 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/tests/JsiIntegrationTest.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/tests/JsiIntegrationTest.cpp
@@ -332,6 +332,42 @@ TYPED_TEST(JsiIntegrationPortableTest, FuseboxSetClientMetadata) {
                                })");
 }
 
+TYPED_TEST(JsiIntegrationPortableTest, ReactNativeApplicationEnable) {
+  this->connect();
+
+  this->expectMessageFromPage(JsonEq(R"({
+                                          "id": 1,
+                                          "result": {}
+                                        })"));
+  this->expectMessageFromPage(JsonEq(R"({
+                                          "method": "ReactNativeApplication.metadataUpdated",
+                                          "params": {
+                                            "integrationName": "JsiIntegrationTest"
+                                          }
+                                        })"));
+
+  this->toPage_->sendMessage(R"({
+                                 "id": 1,
+                                 "method": "ReactNativeApplication.enable",
+                                 "params": {}
+                               })");
+}
+
+TYPED_TEST(JsiIntegrationPortableTest, ReactNativeApplicationDisable) {
+  this->connect();
+
+  this->expectMessageFromPage(JsonEq(R"({
+                                          "id": 1,
+                                          "result": {}
+                                        })"));
+
+  this->toPage_->sendMessage(R"({
+                                 "id": 1,
+                                 "method": "ReactNativeApplication.disable",
+                                 "params": {}
+                               })");
+}
+
 #pragma endregion // AllEngines
 #pragma region AllHermesVariants