diff --git a/packages/react-native/Libraries/Utilities/HMRClient.js b/packages/react-native/Libraries/Utilities/HMRClient.js
index c15cb4eff75..1f67f3e9b9d 100644
--- a/packages/react-native/Libraries/Utilities/HMRClient.js
+++ b/packages/react-native/Libraries/Utilities/HMRClient.js
@@ -23,6 +23,7 @@ const prettyFormat = require('pretty-format');
 const pendingEntryPoints = [];
 let hmrClient = null;
 let hmrUnavailableReason: string | null = null;
+let hmrOrigin: string | null = null;
 let currentCompileErrorMessage: string | null = null;
 let didConnect: boolean = false;
 let pendingLogs: Array<[LogLevel, $ReadOnlyArray<mixed>]> = [];
@@ -100,7 +101,14 @@ const HMRClient: HMRClientNativeInterface = {
   },
 
   registerBundle(requestUrl: string) {
-    invariant(hmrClient, 'Expected HMRClient.setup() call at startup.');
+    invariant(
+      hmrOrigin != null && hmrClient != null,
+      'Expected HMRClient.setup() call at startup.',
+    );
+    // only process registerBundle calls from the same origin
+    if (!requestUrl.startsWith(hmrOrigin)) {
+      return;
+    }
     pendingEntryPoints.push(requestUrl);
     registerBundleEntryPoints(hmrClient);
   },
@@ -162,8 +170,10 @@ const HMRClient: HMRClientNativeInterface = {
 
     const serverScheme = scheme;
 
-    const client = new MetroHMRClient(`${serverScheme}://${serverHost}/hot`);
+    const origin = `${serverScheme}://${serverHost}`;
+    const client = new MetroHMRClient(`${origin}/hot`);
 
+    hmrOrigin = origin;
     hmrClient = client;
 
     const {fullBundleUrl} = getDevServer();