diff --git a/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.cpp b/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.cpp
index 7d5b1acf483..659c8235a64 100644
--- a/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.cpp
+++ b/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.cpp
@@ -92,12 +92,6 @@ CatalystInstanceImpl::initHybrid(jni::alias_ref<jclass>) {
 CatalystInstanceImpl::CatalystInstanceImpl()
     : instance_(std::make_unique<Instance>()) {}
 
-CatalystInstanceImpl::~CatalystInstanceImpl() {
-  if (moduleMessageQueue_ != NULL) {
-    moduleMessageQueue_->quitSynchronous();
-  }
-}
-
 void CatalystInstanceImpl::registerNatives() {
   registerHybrid({
       makeNativeMethod("initHybrid", CatalystInstanceImpl::initHybrid),
diff --git a/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.h b/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.h
index dd9990ef090..c40a691232c 100644
--- a/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.h
+++ b/ReactAndroid/src/main/jni/react/jni/CatalystInstanceImpl.h
@@ -37,7 +37,6 @@ class CatalystInstanceImpl : public jni::HybridClass<CatalystInstanceImpl> {
       "Lcom/facebook/react/bridge/CatalystInstanceImpl;";
 
   static jni::local_ref<jhybriddata> initHybrid(jni::alias_ref<jclass>);
-  ~CatalystInstanceImpl() override;
 
   static void registerNatives();
 
diff --git a/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.cpp b/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.cpp
index 4b5d8d6e953..82fbc928fb6 100644
--- a/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.cpp
+++ b/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.cpp
@@ -31,6 +31,26 @@ JavaTurboModule::JavaTurboModule(const InitParams &params)
       instance_(jni::make_global(params.instance)),
       nativeInvoker_(params.nativeInvoker) {}
 
+JavaTurboModule::~JavaTurboModule() {
+  /**
+   * TODO(T75896241): In E2E tests, instance_ is null. Investigate why. Can we
+   * get rid of this null check?
+   */
+  if (!instance_) {
+    return;
+  }
+
+  nativeInvoker_->invokeAsync([instance = std::move(instance_)]() mutable {
+    /**
+     * Reset the global NativeModule ref on the NativeModules thread. Why:
+     *   - ~JavaTurboModule() can be called on a non-JVM thread. If we reset the
+     *     global ref in ~JavaTurboModule(), we might access the JVM from a
+     *     non-JVM thread, which will crash the app.
+     */
+    instance.reset();
+  });
+}
+
 bool JavaTurboModule::isPromiseAsyncDispatchEnabled_ = false;
 void JavaTurboModule::enablePromiseAsyncDispatch(bool enable) {
   isPromiseAsyncDispatchEnabled_ = enable;
diff --git a/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.h b/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.h
index 642cacb194a..93acda48fcf 100644
--- a/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.h
+++ b/ReactCommon/turbomodule/core/platform/android/JavaTurboModule.h
@@ -41,6 +41,7 @@ class JSI_EXPORT JavaTurboModule : public TurboModule {
   };
 
   JavaTurboModule(const InitParams &params);
+  virtual ~JavaTurboModule();
   jsi::Value invokeJavaMethod(
       jsi::Runtime &runtime,
       TurboModuleMethodValueKind valueKind,