diff --git a/Libraries/Image/ImageStore.js b/Libraries/Image/ImageStore.js
deleted file mode 100644
index 7d6e7be5d6f..00000000000
--- a/Libraries/Image/ImageStore.js
+++ /dev/null
@@ -1,103 +0,0 @@
-/**
- * Copyright (c) Facebook, Inc. and its affiliates.
- *
- * This source code is licensed under the MIT license found in the
- * LICENSE file in the root directory of this source tree.
- *
- * @flow
- * @format
- */
-'use strict';
-
-import NativeImageStore from './NativeImageStore';
-
-const Platform = require('../Utilities/Platform');
-
-const warnOnce = require('../Utilities/warnOnce');
-
-function warnUnimplementedMethod(methodName: string): void {
-  warnOnce(
-    `imagestore-${methodName}`,
-    `react-native: ImageStore.${methodName}() is not implemented on ${
-      Platform.OS
-    }`,
-  );
-}
-
-class ImageStore {
-  /**
-   * Check if the ImageStore contains image data for the specified URI.
-   * @platform ios
-   */
-  static hasImageForTag(uri: string, callback: (hasImage: boolean) => void) {
-    if (NativeImageStore.hasImageForTag) {
-      NativeImageStore.hasImageForTag(uri, callback);
-    } else {
-      warnUnimplementedMethod('hasImageForTag');
-    }
-  }
-
-  /**
-   * Delete an image from the ImageStore. Images are stored in memory and
-   * must be manually removed when you are finished with them, otherwise they
-   * will continue to use up RAM until the app is terminated. It is safe to
-   * call `removeImageForTag()` without first calling `hasImageForTag()`, it
-   * will simply fail silently.
-   * @platform ios
-   */
-  static removeImageForTag(uri: string) {
-    if (NativeImageStore.removeImageForTag) {
-      NativeImageStore.removeImageForTag(uri);
-    } else {
-      warnUnimplementedMethod('removeImageForTag');
-    }
-  }
-
-  /**
-   * Stores a base64-encoded image in the ImageStore, and returns a URI that
-   * can be used to access or display the image later. Images are stored in
-   * memory only, and must be manually deleted when you are finished with
-   * them by calling `removeImageForTag()`.
-   *
-   * Note that it is very inefficient to transfer large quantities of binary
-   * data between JS and native code, so you should avoid calling this more
-   * than necessary.
-   * @platform ios
-   */
-  static addImageFromBase64(
-    base64ImageData: string,
-    success: (uri: string) => void,
-    failure: (error: any) => void,
-  ) {
-    if (NativeImageStore.addImageFromBase64) {
-      NativeImageStore.addImageFromBase64(base64ImageData, success, failure);
-    } else {
-      warnUnimplementedMethod('addImageFromBase64');
-    }
-  }
-
-  /**
-   * Retrieves the base64-encoded data for an image in the ImageStore. If the
-   * specified URI does not match an image in the store, the failure callback
-   * will be called.
-   *
-   * Note that it is very inefficient to transfer large quantities of binary
-   * data between JS and native code, so you should avoid calling this more
-   * than necessary. To display an image in the ImageStore, you can just pass
-   * the URI to an `<Image/>` component; there is no need to retrieve the
-   * base64 data.
-   */
-  static getBase64ForTag(
-    uri: string,
-    success: (base64ImageData: string) => void,
-    failure: (error: any) => void,
-  ) {
-    if (NativeImageStore.getBase64ForTag) {
-      NativeImageStore.getBase64ForTag(uri, success, failure);
-    } else {
-      warnUnimplementedMethod('getBase64ForTag');
-    }
-  }
-}
-
-module.exports = ImageStore;
diff --git a/Libraries/Image/NativeImageStore.js b/Libraries/Image/NativeImageStore.js
deleted file mode 100644
index 0bc4948f1fb..00000000000
--- a/Libraries/Image/NativeImageStore.js
+++ /dev/null
@@ -1,34 +0,0 @@
-/**
- * Copyright (c) Facebook, Inc. and its affiliates.
- *
- * This source code is licensed under the MIT license found in the
- * LICENSE file in the root directory of this source tree.
- *
- * @flow
- * @format
- */
-
-'use strict';
-
-import type {TurboModule} from '../TurboModule/RCTExport';
-import * as TurboModuleRegistry from '../TurboModule/TurboModuleRegistry';
-
-export interface Spec extends TurboModule {
-  // Common
-  +getBase64ForTag: (
-    uri: string,
-    success: (base64ImageData: string) => void,
-    failure: (error: Object) => void,
-  ) => void;
-
-  // iOS-only
-  +hasImageForTag: (uri: string, callback: (hasImage: boolean) => void) => void;
-  +removeImageForTag: (uri: string) => void;
-  +addImageFromBase64: (
-    base64ImageData: string,
-    success: (uri: string) => void,
-    failure: (error: Object) => void,
-  ) => void;
-}
-
-export default TurboModuleRegistry.getEnforcing<Spec>('ImageStoreManager');
diff --git a/Libraries/react-native/react-native-implementation.js b/Libraries/react-native/react-native-implementation.js
index d3602050e7f..1fb35b409b6 100644
--- a/Libraries/react-native/react-native-implementation.js
+++ b/Libraries/react-native/react-native-implementation.js
@@ -61,16 +61,6 @@ module.exports = {
     );
     return require('../Image/ImageEditor');
   },
-  get ImageStore() {
-    warnOnce(
-      'imagestore-deprecation',
-      'ImageStore is deprecated and will be removed in a future release. ' +
-        'To get a base64-encoded string from a local image use either of the following third-party libraries:' +
-        "* expo-file-system: `readAsStringAsync(filepath, 'base64')`" +
-        "* react-native-fs: `readFile(filepath, 'base64')`",
-    );
-    return require('../Image/ImageStore');
-  },
   get InputAccessoryView() {
     return require('../Components/TextInput/InputAccessoryView');
   },
@@ -413,4 +403,18 @@ if (__DEV__) {
       );
     },
   });
+
+  // $FlowFixMe This is intentional: Flow will error when attempting to access ImageStore.
+  Object.defineProperty(module.exports, 'ImageStore', {
+    configurable: true,
+    get() {
+      invariant(
+        false,
+        'ImageStore has been removed from React Native. ' +
+          'To get a base64-encoded string from a local image use either of the following third-party libraries:' +
+          "* expo-file-system: `readAsStringAsync(filepath, 'base64')`" +
+          "* react-native-fs: `readFile(filepath, 'base64')`",
+      );
+    },
+  });
 }