diff --git a/Libraries/Core/setUpBatchedBridge.js b/Libraries/Core/setUpBatchedBridge.js
index 4ceff36bc50..abac069677b 100644
--- a/Libraries/Core/setUpBatchedBridge.js
+++ b/Libraries/Core/setUpBatchedBridge.js
@@ -52,7 +52,7 @@ registerModule('GlobalPerformanceLogger', () =>
   require('../Utilities/GlobalPerformanceLogger'),
 );
 
-if (__DEV__ && !global.__RCTProfileIsProfiling) {
+if (__DEV__) {
   registerModule('HMRClient', () => require('../Utilities/HMRClient'));
 } else {
   registerModule('HMRClient', () => require('../Utilities/HMRClientProdShim'));
diff --git a/Libraries/Core/setUpDeveloperTools.js b/Libraries/Core/setUpDeveloperTools.js
index 9d1a342ada6..06f2079b878 100644
--- a/Libraries/Core/setUpDeveloperTools.js
+++ b/Libraries/Core/setUpDeveloperTools.js
@@ -17,13 +17,11 @@ declare var console: typeof console & {_isPolyfilled: boolean, ...};
  * You can use this module directly, or just require InitializeCore.
  */
 if (__DEV__) {
-  if (!global.__RCTProfileIsProfiling) {
-    require('./setUpReactDevTools');
+  require('./setUpReactDevTools');
 
-    // Set up inspector
-    const JSInspector = require('../JSInspector/JSInspector');
-    JSInspector.registerAgent(require('../JSInspector/NetworkAgent'));
-  }
+  // Set up inspector
+  const JSInspector = require('../JSInspector/JSInspector');
+  JSInspector.registerAgent(require('../JSInspector/NetworkAgent'));
 
   // Note we can't check if console is "native" because it would appear "native" in JSC and Hermes.
   // We also can't check any properties that don't exist in the Chrome worker environment.
diff --git a/Libraries/ReactNative/AppContainer.js b/Libraries/ReactNative/AppContainer.js
index b2e654f729e..cf3f1d0274e 100644
--- a/Libraries/ReactNative/AppContainer.js
+++ b/Libraries/ReactNative/AppContainer.js
@@ -50,10 +50,7 @@ class AppContainer extends React.Component<Props, State> {
 
   componentDidMount(): void {
     if (__DEV__) {
-      if (
-        !global.__RCTProfileIsProfiling &&
-        !this.props.internal_excludeInspector
-      ) {
+      if (!this.props.internal_excludeInspector) {
         this._subscription = RCTDeviceEventEmitter.addListener(
           'toggleElementInspector',
           () => {
@@ -93,12 +90,10 @@ class AppContainer extends React.Component<Props, State> {
   render(): React.Node {
     let logBox = null;
     if (__DEV__) {
-      if (!global.__RCTProfileIsProfiling) {
-        if (!this.props.internal_excludeLogBox) {
-          const LogBoxNotificationContainer =
-            require('../LogBox/LogBoxNotificationContainer').default;
-          logBox = <LogBoxNotificationContainer />;
-        }
+      if (!this.props.internal_excludeLogBox) {
+        const LogBoxNotificationContainer =
+          require('../LogBox/LogBoxNotificationContainer').default;
+        logBox = <LogBoxNotificationContainer />;
       }
     }