diff --git a/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb b/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
index d5089aae641..8d834f53680 100644
--- a/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
+++ b/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
@@ -626,10 +626,10 @@ class UtilsTests < Test::Unit::TestCase
     end
 
     # ==================================== #
-    # Test - Set USE_HERMES Build Setting #
+    # Test - Set build setting             #
     # ==================================== #
 
-    def test_setUseHermesBuildSetting_addTheUserSetting
+    def test_setBuildSetting_addTheUserSetting
         # Arrange
         react_native_path = "react_native/node_modules"
         user_project_mock = prepare_empty_user_project_mock()
@@ -639,23 +639,23 @@ class UtilsTests < Test::Unit::TestCase
         ])
 
         # Act
-        ReactNativePodsUtils.set_use_hermes_build_setting(installer, false)
+        ReactNativePodsUtils.set_build_setting(installer, build_setting: "TEST_SETTING", value: ["Test"])
 
         # Assert
         user_project_mock.build_configurations.each do |config|
-            assert_equal(config.build_settings["USE_HERMES"], false)
+            assert_equal(config.build_settings["TEST_SETTING"], ["Test"])
         end
 
         assert_equal(user_project_mock.save_invocation_count, 1)
         assert_equal(pods_projects_mock.save_invocation_count, 1)
-        assert_equal(Pod::UI.collected_messages, ["Setting USE_HERMES build settings"])
+        assert_equal(Pod::UI.collected_messages, ["Setting TEST_SETTING build settings"])
     end
 
     # ==================================== #
-    # Test - Set Node_Modules User Setting #
+    # Test - Set build setting (Debug)     #
     # ==================================== #
 
-    def test_setNodeModulesUserSettings_addTheUserSetting
+    def test_setBuildSettingDebug_addTheUserSetting
         # Arrange
         react_native_path = "react_native/node_modules"
         user_project_mock = prepare_empty_user_project_mock()
@@ -665,16 +665,18 @@ class UtilsTests < Test::Unit::TestCase
         ])
 
         # Act
-        ReactNativePodsUtils.set_node_modules_user_settings(installer, react_native_path)
+        ReactNativePodsUtils.set_build_setting(installer, build_setting: "TEST_SETTING", value: ["Test"], config_name: "Debug")
 
         # Assert
         user_project_mock.build_configurations.each do |config|
-            assert_equal(config.build_settings["REACT_NATIVE_PATH"], "${PODS_ROOT}/../#{react_native_path}")
+            if config.name == "Debug" then
+                assert_equal(config.build_settings["TEST_SETTING"], ["Test"])
+            end
         end
 
         assert_equal(user_project_mock.save_invocation_count, 1)
         assert_equal(pods_projects_mock.save_invocation_count, 1)
-        assert_equal(Pod::UI.collected_messages, ["Setting REACT_NATIVE build settings"])
+        assert_equal(Pod::UI.collected_messages, ["Setting TEST_SETTING build settings"])
     end
 
     # =================================== #
diff --git a/packages/react-native/scripts/cocoapods/utils.rb b/packages/react-native/scripts/cocoapods/utils.rb
index b5195aadc7c..6b54479738f 100644
--- a/packages/react-native/scripts/cocoapods/utils.rb
+++ b/packages/react-native/scripts/cocoapods/utils.rb
@@ -61,26 +61,15 @@ class ReactNativePodsUtils
         end
     end
 
-    def self.set_use_hermes_build_setting(installer, hermes_enabled)
-        Pod::UI.puts("Setting USE_HERMES build settings")
+    def self.set_build_setting(installer, build_setting:, value:, config_name: nil)
+        Pod::UI.puts("Setting #{build_setting} build settings")
         projects = self.extract_projects(installer)
 
         projects.each do |project|
             project.build_configurations.each do |config|
-                config.build_settings["USE_HERMES"] = hermes_enabled
-            end
-
-            project.save()
-        end
-    end
-
-    def self.set_node_modules_user_settings(installer, react_native_path)
-        Pod::UI.puts("Setting REACT_NATIVE build settings")
-        projects = self.extract_projects(installer)
-
-        projects.each do |project|
-            project.build_configurations.each do |config|
-                config.build_settings["REACT_NATIVE_PATH"] = File.join("${PODS_ROOT}", "..", react_native_path)
+                if config_name == nil || config.name == config_name
+                    config.build_settings[build_setting] = value
+                end
             end
 
             project.save()
diff --git a/packages/react-native/scripts/react_native_pods.rb b/packages/react-native/scripts/react_native_pods.rb
index 77aca67f240..bed94e23868 100644
--- a/packages/react-native/scripts/react_native_pods.rb
+++ b/packages/react-native/scripts/react_native_pods.rb
@@ -285,8 +285,10 @@ def react_native_post_install(
 
   ReactNativePodsUtils.fix_library_search_paths(installer)
   ReactNativePodsUtils.update_search_paths(installer)
-  ReactNativePodsUtils.set_use_hermes_build_setting(installer, hermes_enabled)
-  ReactNativePodsUtils.set_node_modules_user_settings(installer, react_native_path)
+  ReactNativePodsUtils.set_build_setting(installer, build_setting: "USE_HERMES", value: hermes_enabled)
+  ReactNativePodsUtils.set_build_setting(installer, build_setting: "REACT_NATIVE_PATH", value: File.join("${PODS_ROOT}", "..", react_native_path))
+  ReactNativePodsUtils.set_build_setting(installer, build_setting: "SWIFT_ACTIVE_COMPILATION_CONDITIONS", value: ['$(inherited)', 'DEBUG'], config_name: "Debug")
+
   ReactNativePodsUtils.set_ccache_compiler_and_linker_build_settings(installer, react_native_path, ccache_enabled)
   if Environment.new().ruby_platform().include?('darwin')
     ReactNativePodsUtils.apply_xcode_15_patch(installer)
diff --git a/packages/rn-tester/RNTesterPods.xcodeproj/project.pbxproj b/packages/rn-tester/RNTesterPods.xcodeproj/project.pbxproj
index bbb6acb82c0..ce240545a6a 100644
--- a/packages/rn-tester/RNTesterPods.xcodeproj/project.pbxproj
+++ b/packages/rn-tester/RNTesterPods.xcodeproj/project.pbxproj
@@ -950,6 +950,7 @@
 				);
 				REACT_NATIVE_PATH = "${PODS_ROOT}/../../react-native";
 				SDKROOT = iphoneos;
+				SWIFT_ACTIVE_COMPILATION_CONDITIONS = "$(inherited) DEBUG";
 				USE_HERMES = true;
 				WARNING_CFLAGS = (
 					"-Wextra",