diff --git a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridge/queue/MessageQueueThreadHandler.java b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridge/queue/MessageQueueThreadHandler.java
index 010b6871593..ddac0bfec73 100644
--- a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridge/queue/MessageQueueThreadHandler.java
+++ b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridge/queue/MessageQueueThreadHandler.java
@@ -10,6 +10,8 @@ package com.facebook.react.bridge.queue;
 import android.os.Handler;
 import android.os.Looper;
 import android.os.Message;
+import com.facebook.common.logging.FLog;
+import com.facebook.react.common.ReactConstants;
 
 /** Handler that can catch and dispatch Exceptions to an Exception handler. */
 public class MessageQueueThreadHandler extends Handler {
@@ -26,6 +28,15 @@ public class MessageQueueThreadHandler extends Handler {
     try {
       super.dispatchMessage(msg);
     } catch (Exception e) {
+      if (e instanceof NullPointerException) {
+        FLog.e(
+            ReactConstants.TAG,
+            "Caught NullPointerException when dispatching message in MessageQueueThreadHandler. This is likely caused by runnable"
+                + "(msg.callback) being nulled in Android Handler after dispatching and before handling (see T170239922 for more details)."
+                + "Currently we observe that it only happen once which is during initialisation. Due to fixing probably involve Android "
+                + "System code, we decide to ignore here for now and print an error message for debugging purpose in case this cause more serious issues in future.");
+        return;
+      }
       mExceptionHandler.handleException(e);
     }
   }