diff --git a/packages/react-native/scripts/swiftpm/update-xcodeproject.js b/packages/react-native/scripts/swiftpm/update-xcodeproject.js
index e5e11ebe846..4ccf816fabb 100644
--- a/packages/react-native/scripts/swiftpm/update-xcodeproject.js
+++ b/packages/react-native/scripts/swiftpm/update-xcodeproject.js
@@ -30,6 +30,80 @@ function convertXcodeProjectToJSON(projectPath) {
   return JSON.parse(jsonOutput);
 }
 
+/**
+ * Remove all existing SwiftPM package references and dependencies from Xcode project
+ * @param {Object} xcodeProject - The xcode project converted in JSON format
+ */
+function deintegrateSwiftPM(xcodeProject) {
+  const objects = xcodeProject.objects;
+  const objectsToRemove = [];
+
+  // Step 1: Find all PBXNativeTarget objects and clean up their SwiftPM dependencies
+  for (const objectId in objects) {
+    const object = objects[objectId];
+    if (object.isa === "PBXNativeTarget") {
+      // Find PBXFrameworksBuildPhase
+      for (const buildPhaseId of object.buildPhases || []) {
+        const buildPhaseObject = objects[buildPhaseId];
+        if (buildPhaseObject && buildPhaseObject.isa === "PBXFrameworksBuildPhase") {
+          const filesToRemove = [];
+
+          // Check each file in the build phase
+          for (const fileId of buildPhaseObject.files || []) {
+            const buildFileObject = objects[fileId];
+            if (buildFileObject && buildFileObject.isa === "PBXBuildFile" && buildFileObject.productRef) {
+              const productRefObject = objects[buildFileObject.productRef];
+              if (productRefObject && productRefObject.isa === "XCSwiftPackageProductDependency") {
+                // Mark for removal: the product dependency, the build file, and remove from files list
+                objectsToRemove.push(buildFileObject.productRef);
+                objectsToRemove.push(fileId);
+                filesToRemove.push(fileId);
+              }
+            }
+          }
+
+          // Remove files from the build phase
+          if (filesToRemove.length > 0) {
+            buildPhaseObject.files = (buildPhaseObject.files || []).filter(fileId => !filesToRemove.includes(fileId));
+          }
+        }
+      }
+    }
+  }
+
+  // Step 2: Find PBXProject and clean up packageReferences
+  for (const objectId in objects) {
+    const object = objects[objectId];
+    if (object.isa === "PBXProject") {
+      const packageReferencesToRemove = [];
+
+      // Check each package reference
+      for (const packageRefId of object.packageReferences || []) {
+        const packageRefObject = objects[packageRefId];
+        if (packageRefObject && packageRefObject.isa === "XCLocalSwiftPackageReference") {
+          // Mark for removal
+          objectsToRemove.push(packageRefId);
+          packageReferencesToRemove.push(packageRefId);
+        }
+      }
+
+      // Remove package references from the project
+      if (packageReferencesToRemove.length > 0) {
+        object.packageReferences = (object.packageReferences || []).filter(refId => !packageReferencesToRemove.includes(refId));
+      }
+
+      break;
+    }
+  }
+
+  // Step 3: Remove all marked objects
+  for (const objectId of objectsToRemove) {
+    delete objects[objectId];
+  }
+
+  console.log(`✓ Removed ${objectsToRemove.length} SwiftPM-related objects from Xcode project`);
+}
+
 /**
  * Add local SwiftPM package references and product dependencies to Xcode project
  * @param {string} relativePath - The relative path of where the Package.swift is located
@@ -116,6 +190,9 @@ function integrateSwiftPackagesInXcode(xcodeProjectPath, packageSwiftObjects, ap
   // Convert to JSON
   const xcodeProject = convertXcodeProjectToJSON(projectPbxprojPath);
 
+  // Remove any existing SwiftPM integrations first
+  deintegrateSwiftPM(xcodeProject);
+
   // Iterate over PackageSwift objects and execute addLocalSwiftPM
   for (const packageSwift of packageSwiftObjects) {
     addLocalSwiftPM(
@@ -157,6 +234,7 @@ if (require.main === module) {
 module.exports = {
   generateXcodeObjectId,
   convertXcodeProjectToJSON,
+  deintegrateSwiftPM,
   addLocalSwiftPM,
   integrateSwiftPackagesInXcode
 };