diff --git a/packages/react-native-codegen/e2e/__tests__/modules/__snapshots__/GenerateModuleObjCpp-test.js.snap b/packages/react-native-codegen/e2e/__tests__/modules/__snapshots__/GenerateModuleObjCpp-test.js.snap
index a59e8e0a1d0..595b35c34f7 100644
--- a/packages/react-native-codegen/e2e/__tests__/modules/__snapshots__/GenerateModuleObjCpp-test.js.snap
+++ b/packages/react-native-codegen/e2e/__tests__/modules/__snapshots__/GenerateModuleObjCpp-test.js.snap
@@ -17,6 +17,11 @@ exports[`GenerateModuleObjCpp can generate a header file NativeModule specs 1`]
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of RNCodegenModuleFixtures symbols
+#ifndef RNCodegenModuleFixtures_H
+#define RNCodegenModuleFixtures_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -1341,6 +1346,7 @@ inline JS::NativeSampleTurboModuleOptional::Constants::Builder::Builder(Constant
   return i.unsafeRawValue();
 }) {}
 
+#endif // RNCodegenModuleFixtures_H
 "
 `;
 
@@ -1361,6 +1367,11 @@ exports[`GenerateModuleObjCpp can generate a header file NativeModule specs with
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of RNCodegenModuleFixtures symbols
+#ifndef RNCodegenModuleFixtures_H
+#define RNCodegenModuleFixtures_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -2688,6 +2699,7 @@ inline JS::NativeSampleTurboModuleOptional::Constants::Builder::Builder(Constant
 }) {}
 
 NS_ASSUME_NONNULL_END
+#endif // RNCodegenModuleFixtures_H
 "
 `;
 
diff --git a/packages/react-native-codegen/src/generators/modules/GenerateModuleObjCpp/index.js b/packages/react-native-codegen/src/generators/modules/GenerateModuleObjCpp/index.js
index ce4c1048cd3..6b685f1834b 100644
--- a/packages/react-native-codegen/src/generators/modules/GenerateModuleObjCpp/index.js
+++ b/packages/react-native-codegen/src/generators/modules/GenerateModuleObjCpp/index.js
@@ -46,15 +46,20 @@ namespace facebook::react {
 } // namespace facebook::react`;
 
 const HeaderFileTemplate = ({
+  headerFileName,
   moduleDeclarations,
   structInlineMethods,
   assumeNonnull,
 }: $ReadOnly<{
+  headerFileName: string,
   moduleDeclarations: string,
   structInlineMethods: string,
   assumeNonnull: boolean,
-}>) =>
-  `/**
+}>) => {
+  const headerFileNameWithNoExt = headerFileName.replace(/\.h$/, '');
+
+  return (
+    `/**
  * This code was generated by [react-native-codegen](https://www.npmjs.com/package/react-native-codegen).
  *
  * Do not edit this file as changes may cause incorrect behavior and will be lost
@@ -70,6 +75,11 @@ const HeaderFileTemplate = ({
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of ${headerFileNameWithNoExt} symbols
+#ifndef ${headerFileNameWithNoExt}_H
+#define ${headerFileNameWithNoExt}_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -82,11 +92,15 @@ const HeaderFileTemplate = ({
 #import <vector>
 
 ` +
-  (assumeNonnull ? '\nNS_ASSUME_NONNULL_BEGIN\n' : '') +
-  moduleDeclarations +
-  '\n' +
-  structInlineMethods +
-  (assumeNonnull ? '\nNS_ASSUME_NONNULL_END\n' : '\n');
+    (assumeNonnull ? '\nNS_ASSUME_NONNULL_BEGIN\n' : '') +
+    moduleDeclarations +
+    '\n' +
+    structInlineMethods +
+    (assumeNonnull ? '\nNS_ASSUME_NONNULL_END\n' : '\n') +
+    `#endif // ${headerFileNameWithNoExt}_H` +
+    '\n'
+  );
+};
 
 const SourceFileTemplate = ({
   headerFileName,
@@ -197,6 +211,7 @@ module.exports = {
 
     const headerFileName = `${libraryName}.h`;
     const headerFile = HeaderFileTemplate({
+      headerFileName,
       moduleDeclarations: moduleDeclarations.join('\n'),
       structInlineMethods: structInlineMethods.join('\n'),
       assumeNonnull,
diff --git a/packages/react-native-codegen/src/generators/modules/__tests__/__snapshots__/GenerateModuleHObjCpp-test.js.snap b/packages/react-native-codegen/src/generators/modules/__tests__/__snapshots__/GenerateModuleHObjCpp-test.js.snap
index d65cd416670..d65ff73ffff 100644
--- a/packages/react-native-codegen/src/generators/modules/__tests__/__snapshots__/GenerateModuleHObjCpp-test.js.snap
+++ b/packages/react-native-codegen/src/generators/modules/__tests__/__snapshots__/GenerateModuleHObjCpp-test.js.snap
@@ -18,6 +18,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of SampleWithUppercaseName symbols
+#ifndef SampleWithUppercaseName_H
+#define SampleWithUppercaseName_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -45,6 +50,7 @@ namespace facebook::react {
   };
 } // namespace facebook::react
 
+#endif // SampleWithUppercaseName_H
 ",
 }
 `;
@@ -67,6 +73,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of complex_objects symbols
+#ifndef complex_objects_H
+#define complex_objects_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -304,6 +315,7 @@ inline facebook::react::LazyVector<JS::NativeSampleTurboModule::SpecGetArraysOpt
   id const p = _v[@\\"arrayOfObjects\\"];
   return RCTBridgingToVec(p, ^JS::NativeSampleTurboModule::SpecGetArraysOptionsArrayOfObjectsElement(id itemValue_0) { return JS::NativeSampleTurboModule::SpecGetArraysOptionsArrayOfObjectsElement(itemValue_0); });
 }
+#endif // complex_objects_H
 ",
 }
 `;
@@ -326,6 +338,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of cxx_only_native_modules symbols
+#ifndef cxx_only_native_modules_H
+#define cxx_only_native_modules_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -339,6 +356,7 @@ Map {
 
 
 
+#endif // cxx_only_native_modules_H
 ",
 }
 `;
@@ -361,6 +379,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of empty_native_modules symbols
+#ifndef empty_native_modules_H
+#define empty_native_modules_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -388,6 +411,7 @@ namespace facebook::react {
   };
 } // namespace facebook::react
 
+#endif // empty_native_modules_H
 ",
 }
 `;
@@ -410,6 +434,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of native_modules_with_type_aliases symbols
+#ifndef native_modules_with_type_aliases_H
+#define native_modules_with_type_aliases_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -557,6 +586,7 @@ inline std::optional<bool> JS::AliasTurboModule::Options::allowExternalStorage()
   id const p = _v[@\\"allowExternalStorage\\"];
   return RCTBridgingToOptionalBool(p);
 }
+#endif // native_modules_with_type_aliases_H
 ",
 }
 `;
@@ -579,6 +609,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of real_module_example symbols
+#ifndef real_module_example_H
+#define real_module_example_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -799,6 +834,7 @@ inline id<NSObject> _Nullable JS::NativeExceptionsManager::ExceptionData::extraD
   id const p = _v[@\\"extraData\\"];
   return p;
 }
+#endif // real_module_example_H
 ",
 }
 `;
@@ -821,6 +857,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of simple_native_modules symbols
+#ifndef simple_native_modules_H
+#define simple_native_modules_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -910,6 +951,7 @@ inline JS::NativeSampleTurboModule::Constants::Builder::Builder(const Input i) :
 inline JS::NativeSampleTurboModule::Constants::Builder::Builder(Constants i) : _factory(^{
   return i.unsafeRawValue();
 }) {}
+#endif // simple_native_modules_H
 ",
 }
 `;
@@ -932,6 +974,11 @@ Map {
 #ifndef __cplusplus
 #error This file must be compiled as Obj-C++. If you are importing it, you must change your file extension to .mm.
 #endif
+
+// Avoid multiple includes of two_modules_different_files symbols
+#ifndef two_modules_different_files_H
+#define two_modules_different_files_H
+
 #import <Foundation/Foundation.h>
 #import <RCTRequired/RCTRequired.h>
 #import <RCTTypeSafety/RCTConvertHelpers.h>
@@ -975,6 +1022,7 @@ namespace facebook::react {
 } // namespace facebook::react
 
 
+#endif // two_modules_different_files_H
 ",
 }
 `;