diff --git a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridgeless/ReactHost.java b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridgeless/ReactHost.java
index 84e4f82ab58..10ef6bc5234 100644
--- a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridgeless/ReactHost.java
+++ b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/bridgeless/ReactHost.java
@@ -1415,6 +1415,13 @@ public class ReactHost implements ReactHostInterface {
     raiseSoftException(method, reason, ex);
 
     synchronized (mReactInstanceTaskRef) {
+      // Prevent re-destroy when ReactInstance has been reset already, which could happen when
+      // calling destroy multiple times on the same thread
+      ReactInstance reactInstance = mReactInstanceTaskRef.get().getResult();
+      if (reactInstance == null) {
+        return;
+      }
+
       // Retain a reference to current ReactContext before de-referenced by mReactContextRef
       final ReactContext reactContext = getCurrentReactContext();