diff --git a/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.cpp b/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.cpp
index 90f19df8dde..920973fa027 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.cpp
@@ -30,6 +30,21 @@ std::shared_ptr<InstanceAgent> InstanceTarget::createAgent(
   return instanceAgent;
 }
 
+void InstanceTarget::removeExpiredAgents() {
+  // Remove all expired agents.
+  forEachAgent([](auto&) {});
+}
+
+InstanceTarget::~InstanceTarget() {
+  removeExpiredAgents();
+
+  // Agents are owned by the session, not by InstanceTarget, but
+  // they hold an InstanceTarget& that we must guarantee is valid.
+  assert(
+      agents_.empty() &&
+      "InstanceAgent objects must be destroyed before their InstanceTarget. Did you call PageTarget::unregisterInstance()?");
+}
+
 RuntimeTarget& InstanceTarget::registerRuntime(
     RuntimeTargetDelegate& delegate) {
   assert(!currentRuntime_ && "Only one Runtime allowed");
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.h b/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.h
index ae2ed58567a..53a215415f3 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.h
+++ b/packages/react-native/ReactCommon/jsinspector-modern/InstanceTarget.h
@@ -53,6 +53,7 @@ class InstanceTarget {
   InstanceTarget(InstanceTarget&&) = delete;
   InstanceTarget& operator=(const InstanceTarget&) = delete;
   InstanceTarget& operator=(InstanceTarget&&) = delete;
+  ~InstanceTarget();
 
   std::shared_ptr<InstanceAgent> createAgent(
       FrontendChannel channel,